Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus
Identifieur interne : 000326 ( Main/Exploration ); précédent : 000325; suivant : 000327Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus
Auteurs : Sun-Woo Yoon [États-Unis, Corée du Sud] ; Sook-San Wong [États-Unis] ; Huachen Zhu [République populaire de Chine] ; Rirong Chen ; Long Li ; Yu Zhang ; Yi Guan [République populaire de Chine] ; Richard J. Webby [États-Unis]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2017.
Abstract
Infection with 2009 pandemic influenza A(H1N1) virus during pregnancy induces more-severe disease as a consequence of elevated viral loads and innate responses combined with a diminished adaptive response. These factors likely contributed to the increased morbidity and mortality observed in pregnant women during the 2009 pandemic.
Url:
DOI: 10.1093/infdis/jix328
PubMed: 28973317
PubMed Central: 5853788
Affiliations:
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code="subfield">Shantou</wicri:noCountry></affiliation></author><author><name sortKey="Li, Long" sort="Li, Long" uniqKey="Li L" first="Long" last="Li">Long Li</name><affiliation><nlm:aff id="AF0003">Joint Influenza Research Centre, Shantou University Medical College, Shantou</nlm:aff><wicri:noCountry code="subfield">Shantou</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><affiliation><nlm:aff id="AF0003">Joint Influenza Research Centre, Shantou University Medical College, Shantou</nlm:aff><wicri:noCountry code="subfield">Shantou</wicri:noCountry></affiliation></author><author><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><affiliation><nlm:aff id="AF0003">Joint Influenza Research Centre, Shantou University Medical College, Shantou</nlm:aff><wicri:noCountry code="subfield">Shantou</wicri:noCountry></affiliation><affiliation 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Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name><affiliation wicri:level="2"><nlm:aff id="AF0001">Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, Tennessee</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis</wicri:cityArea></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Infection with 2009 pandemic influenza A(H1N1) virus during pregnancy induces more-severe disease as a consequence of elevated viral loads and innate responses combined with a diminished adaptive response. These factors likely contributed to the increased morbidity and mortality observed in pregnant women during the 2009 pandemic.</p></div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Guangdong</li><li>Tennessee</li></region><settlement><li>Shenzhen</li></settlement></list><tree><noCountry><name sortKey="Chen, Rirong" sort="Chen, Rirong" uniqKey="Chen R" first="Rirong" last="Chen">Rirong Chen</name><name sortKey="Li, Long" sort="Li, Long" uniqKey="Li L" first="Long" last="Li">Long Li</name><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name></noCountry><country name="États-Unis"><region name="Tennessee"><name sortKey="Yoon, Sun Woo" sort="Yoon, Sun Woo" uniqKey="Yoon S" first="Sun-Woo" last="Yoon">Sun-Woo Yoon</name></region><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J" last="Webby">Richard J. Webby</name><name sortKey="Wong, Sook San" sort="Wong, Sook San" uniqKey="Wong S" first="Sook-San" last="Wong">Sook-San Wong</name></country><country name="Corée du Sud"><noRegion><name sortKey="Yoon, Sun Woo" sort="Yoon, Sun Woo" uniqKey="Yoon S" first="Sun-Woo" last="Yoon">Sun-Woo Yoon</name></noRegion></country><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Zhu, Huachen" sort="Zhu, Huachen" uniqKey="Zhu H" first="Huachen" last="Zhu">Huachen Zhu</name></region><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><name sortKey="Zhu, Huachen" sort="Zhu, Huachen" uniqKey="Zhu H" first="Huachen" last="Zhu">Huachen Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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